RHL Commentary by Lukman Yusuf
EVIDENCE SUMMARY
Two trials were included in the review. One trial compared an intrapartum regimen of ampicillin plus gentamycin for reducing postpartum infection to the same regimen postpartum (1). Immediate intrapartum treatment seemed to be more effective in reducing neonatal sepsis (relative risk; RR: 0.08, 95% confidential interval CI: 0.00–1.44) and neonatal pneumonia (RR: 0.15, 95% CI: 0.01 to 2.92). The second trial compared a regimen of ampicillin plus gentamycin with ampicillin plus gentamycin plus clindamycin. With both regimens there were similar numbers of newborn complications and fewer cases of postpartum endometritis. However, given that only two trials involving 181 women were eligible for inclusion, the confidence intervals are wide and the evidence base is quite weak.
The review seems to have been conducted satisfactorily.
The full RHL commentary also includes sections on: Relevance
- Magnitude of the problem
- Applicability of the results
- Implementation of the intervention
Research
References
This document should be cited as: Lukman Yusuf. Antibiotic regimens for management of intraamniotic infection: RHL commentary (last revised: 31 August 2004). The WHO Reproductive Health Library, No 9, Update Software Ltd, Oxford, 2006. www.rhlibrary.com
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